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Simultaneous usage of benzodiazepines and opioids may possibly lead to respiratory depression, profound sedation, coma, and Demise—Reserve concomitant prescribing of these prescription drugs for individuals with inadequate alternative remedy selections. Lessen dose for the minimum amount to prevent deadly respiratory melancholy.[26]
Remedy of benzodiazepine overdose will involve protecting the airway, fluid resuscitation, and the use of flumazenil if indicated. Flumazenil will work through aggressive antagonism at the benzodiazepine receptor and will speedily reverse coma.
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When used with treatment - and in accordance With all the individual information leaflet - this medication is normally considered exceptionally Harmless for use for extended time durations.
Define the necessity of strengthening treatment coordination Amongst the interprofessional team to enhance the delivery of care for patients when utilizing diazepam.